Tissue Engineering: Salivary Gland Tissue Engineering
Radiation therapy for head and neck cancer results in atrophy, fibrosis, and degeneration of salivary gland tissue, leading to salivary gland hypofunction and xerostomia. This condition affects approximately 40,000 new patients annually in the US. Xerostomia after radiation therapy results in inability to comfortably swallow, taste or articulate. Salivary immune dysfunction after radiation results in dental decay and oral cavity infections. The quality of life in cancer survivors is markedly diminished. Currently, there is no preventive or curative therapy for xerostomia. We are developing tissue engineering strategies for functional salivary gland regeneration.
1. Pradhan, S.; Liu, C.; Zhang, C.; Jia, X.; Farach-Carson, M. C.; Witt, R. L. "Lumen Formation in Three-Dimensional Cultures of Salivary Acinar Cells" Otolaryngol. Head Neck Surg., 2010, 142, 191-195.
Pradhan, S.; Zhang, C.; Jia, X.; Carson, D. D.; Witt, R.; Farach-Carson, M. C. "Perlecan Domain IV Peptide Stimulates Salivary Gland Cell Assembly in vitro", Tissue Eng Part A. 2009, 15, 3309-3320.