Responsive materials constructed via peptide folding and conseqent self-assembly
Oligopeptides are designed to intramolecularly fold in response to a desired environmental cue. After folding, self-assembly into a desired structure/material occurs. Importantly, by linking peptide folding with self-assembly , material formation is completely reversible providing for materials with properties responsive to the environment surrounding them. This interdisciplinary work involves peptide design through materials characterization. The first examples of responsive materials are extremely dilute but rigid hydrogels completely reversible with pH and temperature.
Ozbas, B.; Kretsinger, J.; Rajagopal, K.; Schneider, J.P.*; Pochan, D.J.* "Salt-Triggered Peptide Folding and Consequent Self-Assembly into Hydrogels with Tunable Modulus," Macromolecules, 2004, in press.
Schneider, J.P.*; Pochan, D.J.*; Ozbas, B.; Rajagopal, K.; Pakstis, L.M. ; Gill, J. "Responsive Hydrogels From the Intramolecular Folding and Self-Assembly of a Designed Peptide" JACS, 2002, 124, 15030-15037
Pochan, D.J.*; Schneider, J.S.*; Kretsinger, J.; Ozbas, B.; Rajagopal, K.; Haines, L. " Thermally Reversible Hydrogels via Intramolecular Folding and Consequent Self-Assembly of a de Novo Designed Peptide" JACS, 2003, 125, 11802-11803.