Vesicle and micelle formation via non-ionic, amphiphilic block copolypeptide self-assembly
Amphiphilic block copolypeptides are designed with PEGylated, nonionic hydrophilic blocks and hydrophobic blocks with varying secondary structure. These molecules are robust membrane and micelle formers in aqueous solution. Molecular parameters (e.g. relative block length, block secondary structure) are chosen in an effort to design a priori a desired assembly shape and size. These designed assemblies hold promise in the areas of drug and cell delivery.
Bellomo, E.G.; Wyrsta, M.D.; Pakstis, L.; Pochan, D.J.; Deming, T.J.*, "Stimuli Responsive Polypeptide Vesicles via Conformation Specific Assembly", Nature Materials, 2004, 3, 244-248.