It is well-recognized that most polymeric implants currently used cause biological encapsulation and foreign body reaction that impair their performances. Ultimately, the implants have to be surgically removed in order to avoid further complications. To mimic the nanoscale topographical features of the natural ECM, we are investigating surface engineering methodology to create functional biointerfaces. We are exploring a range of approaches for the fabrication of surfaces with well-defined topography at the nanometer scale. These nanostructured surfaces are interesting platforms to explore the effects of nanometer scale topography on protein adsorption, and subsequently cell behavior. We are interested in designing surfaces that not only selectively anchor a particular type of protein, but also preserve its natural conformation. Since cells interact with surfaces through the adsorbed protein layer, these surfaces will provide orchestrated healing "signals" to arriving cells, leading to benign cellular reactions and eliminating fibrous capsule formation.
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