Christopher Kloxin

Christopher Kloxin

Associate Professor

Department of Materials Science and Engineering
Chemical & Biomolecular Engineering

Email :
Phone : (302) 831-8670
269 Colburn Lab


Our research group is interested in the molecular engineering of soft materials (i.e., polymers, surfactants, reversible and dynamics assemblies, etc.). We employ a range of synthetic and molecular assembly tools to create new application-tailored materials. Through molecular design, chemistry, and macroscopic property characterization, we continue to refine our understanding of how structure and property are related. Ultimately, we implement our molecular engineering approaches to tackle a wide variety of materials applications from advanced composites to biological therapeutics.


  • Polymer Chemistry Pioneering Investigators 2021
  • ACS PMSE Young Investigator 2018
  • McNair Scholars Outstanding Research Advisor Award 2015
  • University of Delaware Research Foundation (UDRF) Award 2012 & 2014
  • Outstanding Teaching Assistant, 2001 Department of Chemical and Biomolecular Engineering, NCSU
  • Outstanding Undergraduate Teaching Assistant, 1998 & 1999 Department of Chemical Engineering, CU

Research Interests

  • Polymer Chemistry
  • Photopolymerization
  • Peptide Synthesis and Characterization
  • Hybrid Soft Materials
  • Dynamic and Covalent Adaptable Networks

Teaching Interests

  • Macromolecular Design and Bioconjugation
  • Polymer Physics
  • Thermodynamics and Statistical Mechanics

Representative Publications

Bryan P Sutherland, Mukund Kabra, Christopher J Kloxin*, “Expanding the thiol–X toolbox: photoinitiation and materials application of the acid-catalyzed thiol–ene (ACT) reaction,” Polymer Chemistry, 12 (10) 1562-1570 (2021).  DOI: 10.1039/D0PY01593H

Sutherland, B.P.; LeValley, P.J.; Bischoff, D.J.; Kloxin, A.M.; Kloxin C.J.*; “Sequence-defined vinyl sulfonamide click nucleic acids (VS-CNAs) and their assembly into dynamically responsive materials,” Chemical Communications 56 (76), 11263-11266 (2020).  DOI: 10.1039/D0CC04235H

Wu, D.; Sinha, N.; Lee J.; Zhang, H.; Saven, J.*; Kloxin, C.J.*, Pochan, D.J.*, “Polymers with Controlled Assembly and Rigidity Made with Click-functional Peptide Bundles,” Nature 574 (7780) 658-662 (2019) DOI: 10.1038/s41586-019-1683-4

Sutherland, B.P.; El-Zaatari, B.M.; Halaszynski, N.I.; French, J.M.; Bai, S.; Kloxin, C.J.*, “On-Resin Macrocyclization of Peptides Using Vinyl Sulfonamides as a Thiol-Michael ‘Click’ Acceptor,” Bioconjugate Chemistry 29 (12) 3987-3992 (2018)  DOI: 10.1021/acs.bioconjchem.8b00751

Nicastro, K.H.; Kloxin, C.J.*; Epps, T.H.*, “Potential Lignin-Derived Alternatives to Bisphenol A in Diamine-Hardened Epoxy Resins,” ACS Sustainable Chemistry and Engineering 6 (11) 14812-14819 (2018). DOI: 10.1021/acssuschemeng.8b03340

Shete, A.U.; El-Zaatari, B.M.; French, J.M.; & Kloxin, C.J.*, “Blue-light activated rapid polymerization for defect-free bulk Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) crosslinked networks,” Chemical Communications, 52 10574-10577 (2016) DOI: 10.1039/C6CC05095F

Kloxin C.J. & Bowman C.N., “Covalent adaptable networks: smart, reconfigurable and responsive network systems,” Chemical Society Reviews 42 (17), 7161-7173 (2013) DOI: 10.1039/C3CS60046G

Adzima, B.J.; Kloxin, C.J.; DeForest, C.A.; Anseth, K.S.; & Bowman, C.N., “Photofixation lithography in Diels—Alder Networks,” Macromolecular Rapid Communications 33 (24) 2092-2096 (2012) DOI: 10.1002/marc.201200599

Kloxin, C.J.; Scott, T.F.; Park, H.; & Bowman, C.N., “Mechanophotopatterning on a Photoresponsive Elastomer”, Advanced Materials 23 (17) 1977-1981 (2011) DOI: 10.1002/adma.201100323

Adzima, B.J.; Tao, Y.; Kloxin, C.J.; DeForest, C.A.; Anseth, K.S.; & Bowman, C.N., “Spatial and temporal control of the alkyne—azide cycloaddition by photoinitiated Cu(II) reduction”, Nature Chemistry 3, 258-261 (2011) DOI: 10.1038/nchem.980